Molecular regulation of T cell responses in human cancer

T cells can largely infiltrate human tumors but fail to provide long-term control of cancer growth due to acquired dysfunction and immunosuppression in the tumor microenvironment. We have discovered stem-like T cell populations with capability to mediate superior anti-tumor T cell responses. I will discuss the molecular properties of these cells in relation to dysfunctional mechanisms and immunosuppression by CD4+ regulatory T cells (Treg). In this regard, I will also illustrate novel molecular regulators specifying the Treg identity in cancer.