Séminaire
28 mars
2022

Tuning of actin remodeling as driving force for the adaptable activities of T lymphocytes

Le 28 mars - 11h-23h
Centre de recherche - Paris - Amphithéâtre Constant-Burg - 12 rue Lhomond, Paris 5e
12 rue Lhomond, Paris 5ème
Description

The activation and function of T lymphocytes is determined by their ability to migrate and to assemble immunological synapses with antigen-presenting cells. Such dynamic properties are highly dependent on actin cytoskeleton remodeling. My research activity has focused on elucidating the molecular control of actin cytoskeleton remodeling in T lymphocytes via the prism of rare immunodeficiencies due to mutations in genes encoding actin binding proteins and upstream regulators. I will present the application of high-content cell imaging as a platform to systematically assess defects in motility and synapse phenotypes in T lymphocytes from patients with distinct gene defects. I will also introduce our current efforts to understand how T lymphocytes decode the triggering of co-stimulatory and co-inhibitory receptors into selective actin remodeling programs to tune immunological synapse stability. Finally, I will discuss the topic related to the energetic cost of actin remodeling in the context of T lymphocyte activation.

Orateurs
Loïc
Dupré
Institut Infinity INSERM, CHU Purpan, Toulouse
Invité(es) par
Ana-Maria
Lennon
Claire
Hivroz
Institut Curie
Contact
Elodie
Mieville