Post-Doctoral position

Laboratory

The research group DNA repair mechanisms in cancers (Ceccaldi Lab, https://institut-curie.org/team/ceccaldi) is seeking a post-doctoral researcher driving cutting-edge research projects aiming at understanding the mechanisms regulating genome stability.

In the recent years, our team significant contributions to the field of genome stability and tumor biology. Focusing on compensatory mechanisms employed by cancer cells with defects in homologous recombination (HR)-mediated repair, we shed light on new mechanisms and pathways controlling genome stability and Homologous Recombination (HR)-deficient tumor survival.

From a translational point of view, our group has identified (and developed inhibitors against) new drug targets for the treatment of breast and ovarian tumors target and highlighted the importance of studying the relationships between the different DNA repair pathways to better understand their interaction and exploit them for therapeutic purposes. Our long-term research goals hinge on the critical need for 1) new scientific approaches to discover additional regulators and effectors of genome stability, 2) basic understanding of interconnections between DNA repair processes, and 3) new drug development and biomarkers for anticancer targeted therapy.

Recent publication from the team

1.             Zhou, J. et al. A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors. Nature Cancer, 2021.

2.             Gelot, C. et al. Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis. Nature, 2023.

9.             Kovacs, M. T. et al. DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A/C. Molecular Cell, 2023.

8.             Musiani, D. et al. SMUG1 trapping at unprocessed uracil upon UNG inhibition triggers homologous recombination and selectively kills BRCA1/2-deficient tumors. In revision, 2024.

Missions

To investigate new mechanisms that regulate the DNA damage response and repair pathways. A key aspect of the project will focus on evaluating the role of these mechanism(s) in tumor progression.

Prospective postdoc applicants have a Ph.D degree in molecular biology, biochemistry or genetics. The ideal applicant has further expertise in proteomics or microscopy. She/he has a strong publication record with at least one first-author paper published in a high-profile journal, allowing her/him to apply for competitive stipends/fellowships and to finally proceed towards an independent academic research position. Great communication skills are needed, together with appropriate organizational capacity.

Professional English and/or French level required.

All our opportunities are open to people with disabilities

Contract information

Type of contract: Fixed-term contract

Starting date:  From November 2024

Duration: 3 years

Working time: Full time / 211 days per year

Remuneration: according to the current grids

Benefits: Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance

Location of the position: Paris

Contact

Please send your application including your CV, a letter of motivation explaining why you would like to join our team and contact information of at least two referees.

Publication date: August 2024

Deadline for application:  October 31st 2024

Applications will be considered as they are received and until a candidate is selected.

Institut Curie is an inclusive, equal opportunity employer

and is dedicated to the highest standards of research integrity.

https://euraxess.ec.europa.eu/sites/default/files/brochures/eur_21620_en-fr.pdf