Ingénieur de recherche
Recherche - Paris
Spécialités / domaines
Biologie des systèmes,
Intelligence artificielle,
Single Cell

I am a permanent senior researcher working at Institut Curie since 2005. I co-lead and coordinate scientific projects of Computational Systems Biology of Cancer team inside Bioinformatics of Cancer department.

From 2019, I hold an interdisciplinary chair at Prairie - PaRis Artificial Intelligence Research InstitutE. PRAIRIE pursues fundamental research in core areas of AI as well as interdisciplinary work at its interface with sciences and applications. My research focus at PRAIRIE is at studying the geometry of high-dimensional spaces of multi-omics data, including single cell data which become abundant in biological research.

My university education was in theoretical physics (cosmology, models of closed Universe with conformal metrics). I did my PhD in computer science under supervision of Alexander Gorban on the subject of developing a computationally effective method of elastic maps for constructing non-linear principal manifolds by suggesting an optimization-based generalisation of self-organizing maps. After spending 3 years of post-doc in the French analogue of Advanced Studies Institute, Institut des Hautes Etudes Scientifiques (IHES), I got a permanent researcher position at Institut Curie with a mission to participate in building and defining strategy of a new systems biology research group.

I co-author about 130 peer-reviewed pubications, 3 books and 20 book chapters. I (co-)supervised 12 PhD students. I am an active scientific software developer. I have rich experience of scientific and industrial collaborations. I teach short courses on data integration and application of machine learning in cancer research. I constantly participate in organization of courses, workshops and conferences.

Interpreting pathways to discover cancer driver genes with Moonlight
Nature Communications
Antonio Colaprico, Catharina Olsen, Matthew H. Bailey, Gabriel J. Odom, Thilde Terkelsen, Tiago C. Silva, André V. Olsen, Laura Cantini, Andrei Zinovyev, Emmanuel Barillot, Houtan Noushmehr, Gloria Bertoli, Isabella Castiglioni, Claudia Cava, Gianluca Bontempi, Xi Steven Chen, Elena Papaleo