Distinct anterograde trafficking pathways of BACE1 and amyloid precursor protein from the TGN and the regulation of amyloid-β production

Nom de la revue
Molecular Biology of the Cell
Jing Zhi A. Tan, Lou Fourriere, Jingqi Wang, Franck Perez, Gaelle Boncompain, Paul A. Gleeson

The anterograde trafficking of BACE1 and the potential processing of amyloid precursor protein along the secretory pathway remain poorly defined. Our findings reveal that Golgi exit of BACE1 and APP in primary neurons is tightly regulated, resulting in their segregation along different transport routes, which limits APP processing.