Targeting chronic lymphocytic leukemia with N-methylated thrombospondin-1–derived peptides overcomes drug resistance

Blood Advances
Elodie Pramil, Linda Herbi Bastian, Thomas Denèfle, Fariba Nemati, Malina Xiao, Eva Lardé, Karim Maloum, Damien Roos-Weil, Elise Chapiro, Magali Le Garff-Tavernier, Frédéric Davi, Didier Decaudin, Marika Sarfati, Florence Nguyen-Khac, Hélène Merle-Béral, Philippe Karoyan, Santos A. Susin
DOI
10.1182/bloodadvances.2019000350
Abstract

Key PointsN-methylated thrombospondin-1 mimetic peptides selectively kill the leukemic CD5+ B cells, sparing mature and precursor nontumor cells. CD47 peptide triggering eliminates drug-resistant CLL cells by inducing an original form of cell death regulated by G proteins.

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