ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

Repairing tears in the nuclear envelope

The nuclear envelope segregates genomic DNA from the cytoplasm and regulates protein trafficking between the cytosol and the nucleus. Maintaining nuclear envelope integrity during interphase is considered crucial. However, Raab
et al.
and Denais
et al.
show that migrating immune and cancer cells experience frequent and transitory nuclear envelope ruptures when they move through tight spaces (see the Perspective by Burke). The nuclear envelope reseals rapidly during interphase, assisted by components of the ESCRT III membrane-remodeling machinery.

Science
, this issue pp.
359
and
353
; see also p.
295