Harnessing an emissive guanine surrogate to design small-molecule fluorescent chemosensors of O6-methylguanine-DNA-methyltransferase (MGMT)

Nom de la revue
Organic & Biomolecular Chemistry
Alexandra Fillion, Jaime Franco Pinto, Anton Granzhan
Abstract

Activity of O6-methylguanine-DNA-methyltransferase (MGMT) can be monitored in real time using chemosensors that generate an emissive guanine analogue thienoguanine (thGN).