ANTON GRANZHAN

Docteur,

Chargé de recherche CNRS

Recherche - Orsay

Spécialités / domaines

Biologie et chimie des radiations, signalisation cellulaire et cancer,

Chimie

Fonctions au sein de l'Institut Curie :

Chef d'équipe de recherche

Chimie et Reconnaissance d'acides nucléiques
Unité : Chimie et Modélisation pour la Biologie du Cancer (UMR9187 / U1196)

Publications

2024

Integrated High-Throughput Screening and Large-Scale Isobolographic Analysis to Accelerate the Discovery of Radiosensitizers With Greater Selectivity for Cancer Cells

International Journal of Radiation Oncology*Biology*Physics

Pierre Verrelle, Pierre Gestraud, Florent Poyer, Adèle Soria, Sarah Tessier, Aurianne Lescure, Elodie Anthony, Maxime Corbé, Sophie Heinrich, Claire Beauvineau, Ludovic Chaput, Anton Granzhan, Sandrine Piguel, Franck Perez, Marie-Paule Teulade-Fichou, Frédérique Megnin-Chanet, Elaine Del Nery

(2024 avr 01)

2023

Unprecedented reactivity of polyamines with aldehydic DNA modifications: structural determinants of reactivity, characterization and enzymatic stability of adducts

Nucleic Acids Research

Eka Putra Gusti Ngurah Putu, Laurent Cattiaux, Thomas Lavergne, Yves Pommier, Sophie Bombard, Anton Granzhan

(2023 oct 18)

2023

Alternative splicing of BCL-x is controlled by RBM25 binding to a G-quadruplex in BCL-x pre-mRNA

Nucleic Acids Research

Ronan Le Sénéchal, Marc Keruzoré, Alicia Quillévéré, Nadège Loaëc, Van-Trang Dinh, Oksana Reznichenko, Pedro Guixens-Gallardo, Laurent Corcos, Marie-Paule Teulade-Fichou, Anton Granzhan, Marc Blondel

(2023 oct 09)

2023

Solution and Gas-Phase Stability of DNA Junctions from Temperature-Controlled Electrospray Ionization and Surface-Induced Dissociation

Analytical Chemistry

Adam Pruška, Julian A. Harrison, Anton Granzhan, Adrien Marchand, Renato Zenobi

(2023 Sep 12)

2023

Optimization of G‐Quadruplex Ligands through a SAR Study by Combining Parallel Synthesis and Screening of Cationic Bis(acylhydrazones)

Chemistry – A European Journal

Oksana Reznichenko, Denis Leclercq, Jaime Franco Pinto, Liliane Mouawad, Valérie Gabelica, Anton Granzhan

(2023 jan 18)

2023

Novel Synthesis of IMC-48 and Affinity Evaluation with Different i-Motif DNA Sequences

Molecules

Florian Berthiol, Joseph Boissieras, Hugues Bonnet, Marie Pierrot, Christian Philouze, Jean-François Poisson, Anton Granzhan, Jérôme Dejeu, Eric Defrancq

(2023 jan 10)

2022

The different activities of RNA G-quadruplex structures are controlled by flanking sequences

Life Science Alliance

Alice J-L Zheng, Aikaterini Thermou, Pedro Guixens Gallardo, Laurence Malbert-Colas, Chrysoula Daskalogianni, Nathan Vaudiau, Petter Brohagen, Anton Granzhan, Marc Blondel, Marie-Paule Teulade-Fichou, Rodrigo Prado Martins, Robin Fahraeus

(2022 fév 01)

2022

Acridine–O6-benzylguanine hybrids: Synthesis, DNA binding, MGMT inhibition and antiproliferative activity

European Journal of Medicinal Chemistry

Jaime Franco Pinto, Alexandra Fillion, Patricia Duchambon, Sophie Bombard, Anton Granzhan

(2022 jan 01)

2022

Assessment of presumed small-molecule ligands of telomeric i-DNA by BioLayer Interferometry (BLI)

Chemical Communications

Hugues Bonnet, Maeva Morel, Alexandre Devaux, Joseph Boissieras, Anton Granzhan, Benjamin Elias, Thomas Lavergne, Jérôme Dejeu, Eric Defrancq

(2022 jan 01)

2022

Harnessing an emissive guanine surrogate to design small-molecule fluorescent chemosensors of O6-methylguanine-DNA-methyltransferase (MGMT)

Organic & Biomolecular Chemistry

Alexandra Fillion, Jaime Franco Pinto, Anton Granzhan

(2022 jan 01)