Advancing Optical Imaging and Neural Network Models to Unravel Brain-Wide Dynamics in Larval Zebrafish

I will first present our recent advancements in optical light-sheet microscopy tools for recording both stimulus-driven and spontaneous brain-wide neural activity in larval zebrafish. Using these tools, we study how neural activity in larval zebrafish is linked to behavioral motifs, with a focus on postural control and multisensory integration. I will then discuss our findings from training artificial neural network models on recordings of spontaneous neural activity to uncover large-scale organizational principles underlying brain dynamics.