Cryo-EM and cryo-ET of membrane remodeling in autophagy and endolysosomes

James H. Hurley is a leading structural biologist (https://vcresearch.berkeley.edu/faculty/james-hurley),  whose work has transformed our understanding of the interplay between proteins and membrane lipids.  He is especially known for seminal studies to uncover molecular mechanism of the ESCRT machinery, HIV trafficking, retrograde trafficking by retromer, and the autophagy core complexes, combining crystallography, cryo-EM, and reconstitution on model membranes to explain how cells sort cargo, remodel membranes, and initiate autophagy  (https://scholar.google.com/citations?user=SoNEZA8AAAAJ&hl=en).