Innate Immune Activation by HIV-1

Liste de publications:

Expression of intron-containing HIV-1 RNA induces NLRP1 inflammasome activation in myeloid cells.
Jalloh S, Hughes IK, Akiyama H, Gojanovich AD, Quiñones-Molina AA, Yang M, Henderson AJ, Mostoslavsky G, Gummuluru S. PLoS Biol. 2025 Sep 8;23(9):e3003320. doi: 10.1371/journal.pbio.3003320. eCollection 2025 Sep.PMID: 40920844 
 
5' cap sequestration is required for sensing of unspliced HIV-1 RNA by MDA5.
Hughes IK, Kharytonchyk S, Ramaswamy S, Jalloh S, Hood JB, He X, Henderson AJ, Akiyama H, Telesnitsky A, Gummuluru S. bioRxiv [Preprint]. 2025 Aug 25:2025.08.20.671346. doi: 10.1101/2025.08.20.671346.PMID: 40909469 
 
The macrophage-intrinsic MDA5/IRF5 axis drives HIV-1 intron-containing RNA-induced inflammatory responses.
Ramaswamy S, Akiyama H, Berrigan J, Quiñones-Molina AA, Olson AJ, Chen Y, Liang Y, Henderson AJ, Asundi A, Sagar M, Gummuluru S. J Clin Invest. 2025 Jun 10;135(16):e187663. doi: 10.1172/JCI187663. eCollection 2025 Aug 15.PMID: 40493408
 
Evasion of CARD8 Activation During HIV-1 Assembly.
Hughes IK, Hood JB, Quiñones-Molina AA, Akiyama H, Gummuluru S. bioRxiv [Preprint]. 2025 May 19:2025.05.19.654850. doi: 10.1101/2025.05.19.654850.PMID: 40475532
 
HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction.
Akiyama H, Miller CM, Ettinger CR, Belkina AC, Snyder-Cappione JE, Gummuluru S. Nat Commun. 2018 Aug 27;9(1):3450. doi: 10.1038/s41467-018-05899-7.PMID: 30150664