Lipid nanoparticles for mRNA vaccine delivery

mRNA vaccines proved to be very successful during the COVID-19 pandemic. The most advanced platform uses nucleoside-modified mRNA formulated in lipid nanoparticles (LNPs). Both the mRNA and LNP design and chemistry contribute to the immunostimulatory properties of mRNA vaccines. Dr. Pardi's seminar will discuss how the composition of LNPs can be tailored to induce more cellular- or humoral-focused immune responses based on the vaccine application.