PHILIPPE CHAVRIER

Docteur,

Directeur de recherche CNRS

Recherche - Paris

Spécialités / domaines

Physique-chimie-biologie multi-échelle et cancer (molécules, cellules, tissus et organismes)

Fonctions au sein de l'Institut Curie :

Chef d'équipe de recherche

Dynamique de la membrane et du cytosquelette
Unité : Biologie cellulaire et Cancer (UMR144)

Publications

2023

Multiscale model of the different modes of cancer cell invasion

Bioinformatics

Marco Ruscone, Arnau Montagud, Philippe Chavrier, Olivier Destaing, Isabelle Bonnet, Andrei Zinovyev, Emmanuel Barillot, Vincent Noël, Laurence Calzone

(2023 juin 01)

2021

Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion

Cell

Guilherme Pedreira de Freitas Nader, Sonia Agüera-Gonzalez, Fiona Routet, Matthieu Gratia, Mathieu Maurin, Valeria Cancila, Clotilde Cadart, Andrea Palamidessi, Rodrigo Nalio Ramos, Mabel San Roman, Matteo Gentili, Ayako Yamada, Alice Williart, Catalina Lodillinsky, Emilie Lagoutte, Catherine Villard, Jean-Louis Viovy, Claudio Tripodo, Jérôme Galon, Giorgio Scita, Nicolas Manel, Philippe Chavrier, Matthieu Piel

(2021 Sep 01)

2021

mTOR Repression in Response to Amino Acid Starvation Promotes ECM Degradation Through MT1‐MMP Endocytosis Arrest

Advanced Science

Cecilia Colombero, David Remy, Sandra Antoine‐Bally, Anne‐Sophie Macé, Pedro Monteiro, Nadia ElKhatib, Margot Fournier, Ahmed Dahmani, Elodie Montaudon, Guillaume Montagnac, Elisabetta Marangoni, Philippe Chavrier

(2021 Sep 01)

2021

Metastasis-suppressor NME1 controls the invasive switch of breast cancer by regulating MT1-MMP surface clearance

Oncogene

Catalina Lodillinsky, Laetitia Fuhrmann, Marie Irondelle, Olena Pylypenko, Xiao-Yan Li, Hélène Bonsang-Kitzis, Fabien Reyal, Sophie Vacher, Claire Calmel, Olivier De Wever, Ivan Bièche, Marie-Lise Lacombe, Ana Maria Eiján, Anne Houdusse, Anne Vincent-Salomon, Stephen J. Weiss, Philippe Chavrier, Mathieu Boissan

(2021 juin 10)

2020

Intersection of TKS5 and FGD1/CDC42 signaling cascades directs the formation of invadopodia

Journal of Cell Biology

Anna Zagryazhskaya-Masson, Pedro Monteiro, Anne-Sophie Macé, Alessia Castagnino, Robin Ferrari, Elvira Infante, Aléria Duperray-Susini, Florent Dingli, Arpad Lanyi, Damarys Loew, Elisabeth Génot, Philippe Chavrier

(2020 Sep 07)

2020

Protrudin-mediated ER–endosome contact sites promote MT1-MMP exocytosis and cell invasion

Journal of Cell Biology

Nina Marie Pedersen, Eva Maria Wenzel, Ling Wang, Sandra Antoine, Philippe Chavrier, Harald Stenmark, Camilla Raiborg

(2020 Aoû 03)

2020

A new pipeline for pathophysiological analysis of the mammary gland based on organoid transplantation and organ clearing

Journal of Cell Science

Emilie Lagoutte, Clémentine Villeneuve, Vincent Fraisier, Denis Krndija, Marie-Ange Deugnier, Philippe Chavrier, Carine Rossé

(2020 juin 15)

2019

MT1-MMP directs force-producing proteolytic contacts that drive tumor cell invasion

Nature Communications

Robin Ferrari, Gaëlle Martin, Oya Tagit, Alan Guichard, Alessandra Cambi, Raphaël Voituriez, Stéphane Vassilopoulos, Philippe Chavrier

(2019 déc 01)

2019

aPKCi triggers basal extrusion of luminal mammary epithelial cells by tuning contractility and vinculin localization at cell junctions

Proceedings of the National Academy of Sciences

Clémentine Villeneuve, Emilie Lagoutte, Ludmilla de Plater, Samuel Mathieu, Jean-Baptiste Manneville, Jean-Léon Maître, Philippe Chavrier, Carine Rossé

(2019 nov 26)

2019

Nucleus–Invadopodia Duo During Cancer Invasion

Trends in Cell Biology

Robin Ferrari, Elvira Infante, Philippe Chavrier

(2019 fév 01)