AGuIX nanoparticle-nanobody bioconjugates to target immune checkpoint receptors

Nanoscale
Léna Carmès, Guillaume Bort, François Lux, Léa Seban, Paul Rocchi, Zeinaf Muradova, Agnès Hagège, Laurence Heinrich-Balard, Frédéric Delolme, Virginie Gueguen-Chaignon, Charles Truillet, Stephanie Crowley, Elisa Bello, Tristan Doussineau, Michael Dougan, Olivier Tillement, Jonathan D. Schoenfeld, Needa Brown, Ross Berbeco
DOI
10.1039/d3nr04777f
Abstract

Comparison of click chemistry and sortagging grafting strategies for functionalizing AGuIX nanoparticles with nanobodies to develop a tri-functional technology combining MRI imaging, radiotherapy, and immunotherapy by inhibiting immune checkpoints.

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