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Dynamics of the membrane-cytoskeleton interface in MHC class II-restricted antigen presentation

1 juil. 2016Immunological Reviews

DOI : 10.1111/imr.12429

Auteurs

Marine Bretou, Anita Kumari, Odile Malbec, Hélène D. Moreau, Dorian Obino, Paolo Pierobon, Violaine Randrian, Pablo J. Sáez, Ana-Maria Lennon-Duménil

Résumé

Summary

Antigen presentation refers to the ability of cells to show MHC‐associated determinants to T lymphocytes, leading to their activation. MHC class II molecules mainly present peptide‐derived antigens that are internalized by endocytosis in antigen‐presenting cells (APCs). Here, we describe how the interface between cellular membranes and the cytoskeleton regulates the various steps that lead to the presentation of exogenous antigens on MHC class II molecules in the two main types of APCs: dendritic cells (DCs) and B lymphocytes. This includes antigen uptake, processing, APC migration, and APC–T cell interactions. We further discuss how the interaction between APC‐specific molecules and cytoskeleton elements allows the coordination of antigen presentation and cell migration in time and space.

Membres

ANA-MARIA LENNON DUMENIL

Directeur de recherche Inserm

HELENE MOREAU

Chargé de recherche Inserm