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Efficient inhibition of human AP endonuclease 1 (APE1) via substrate masking by abasic site-binding macrocyclic ligands

1 janv. 2015Chemical Communications

DOI : 10.1039/c5cc06084b

Auteurs

Naoko Kotera, Florent Poyer, Anton Granzhan, Marie-Paule Teulade-Fichou

Résumé

Bis-naphthalene macrocycles bind to abasic sites in DNA, leading to efficient inhibition of their cleavage by human AP endonuclease 1 (APE1).

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