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- Genetic and environmental modulation of transposition shapes the evolutionary potential of Arabidopsis thaliana
Genetic and environmental modulation of transposition shapes the evolutionary potential of Arabidopsis thaliana
Auteurs
Pierre Baduel, Basile Leduque, Amandine Ignace, Isabelle Gy, José Gil, Olivier Loudet, Vincent Colot, Leandro Quadrana
Résumé
Abstract
Background
How species can adapt to abrupt environmental changes, particularly in the absence of standing genetic variation, is poorly understood and a pressing question in the face of ongoing climate change. Here we leverage publicly available multi-omic and bio-climatic data for more than 1000 wild
Results
We demonstrate that TE insertions arise at almost the same rate as base substitutions. Mobilization activity of individual TE families varies greatly between accessions, in association with genetic and environmental factors as well as through complex gene-environment interactions. Although the distribution of TE insertions across the genome is ultimately shaped by purifying selection, reflecting their typically strong deleterious effects when located near or within genes, numerous recent TE-containing alleles show signatures of positive selection. Moreover, high rates of transposition appear positively selected at the edge of the species’ ecological niche. Based on these findings, we predict through mathematical modeling higher transposition activity in Mediterranean regions within the next decades in response to global warming, which in turn should accelerate the creation of large-effect alleles.
Conclusions
Our study reveals that TE mobilization is a major generator of genetic variation in