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High-throughput microfluidic micropipette aspiration device to probe time-scale dependent nuclear mechanics in intact cells

1 janv. 2019Lab on a Chip

DOI : 10.1039/c9lc00444k

Auteurs

Patricia M. Davidson, Gregory R. Fedorchak, Solenne Mondésert-Deveraux, Emily S. Bell, Philipp Isermann, Denis Aubry, Rachele Allena, Jan Lammerding

Résumé

We report the development, validation, and application of an easy-to-use microfluidic micropipette aspiration device and automated image analysis platform that enables high-throughput measurements of the viscoelastic properties of cell nuclei.