Lysosome signaling controls the migration of dendritic cells

Science Immunology
Marine Bretou, Pablo J. Sáez, Doriane Sanséau, Mathieu Maurin, Danielle Lankar, Melanie Chabaud, Carmine Spampanato, Odile Malbec, Lucie Barbier, Shmuel Muallem, Paolo Maiuri, Andrea Ballabio, Julie Helft, Matthieu Piel, Pablo Vargas, Ana-Maria Lennon-Duménil
DOI
10.1126/sciimmunol.aak9573
Abstract

Lysosomes control dendritic cell migration by linking macropinocytosis to cytoskeletal rearrangement via the TFEB-TRPML1 axis.

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