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Pressure sensing through Piezo channels controls whether cells migrate with blebs or pseudopods

4 févr. 2020Proceedings of the National Academy of Sciences

DOI : 10.1073/pnas.1905730117

Auteurs

Nishit Srivastava, David Traynor, Matthieu Piel, Alexandre J. Kabla, Robert R. Kay

Résumé

Significance

Cells migrating within the body perform vital functions in development and for defense and repair of tissues. In this dense environment, cells encounter mechanical forces and constraints not experienced when moving under buffer, and, accordingly, many change how they move. We find that gentle squashing, which mimics mechanical resistance, causes cells to move using blebs—a form of projection driven by fluid pressure—rather than pseudopods. This behavior depends on the Piezo stretch-operated ion channel in the cell membrane and calcium fluxes into the cell. Piezo is highly conserved and is required for light touch sensation; this work extends its functions into migrating cells.