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- Taxonomic and functional profiling of skin microbiome in psoriasis
Taxonomic and functional profiling of skin microbiome in psoriasis
Auteurs
Hanna Sinkko, Peter Olah, Ying Yang, Guilherme Maia, Mauricio Barrientos-Somarribas, Zoltan Rádai, Kuunsade Mäenpää, Tatiany Sorratto, Alexander Salava, Antti Lauerma, Jonathan Barker, Annamari Ranki, Bernhard Homey, Bjorn Andersson, Nanna Fyhrquist, Harri Alenius, , Juha Kere, Tiina Skoog, Francesca Levi-Schaffer, Dario Greco, Stefanie Prast-Nielsen, Vassili Soumelis, Sophia Tsoka, Jens M Schröder, Frank O Nestle, Philippe Hupé
Résumé
This research utilizes whole metagenomic shotgun sequencing to analyze the skin microbiome in psoriasis patients, comparing lesional and non-lesional skin with that of healthy individuals. The study identifies significant differences in the microbial composition and functionality between psoriatic and healthy skin, revealing distinct microbial patterns and disruptions in psoriatic skin. These findings highlight the complex role of skin microbiota in psoriasis, emphasizing variations in bacteria and their functional characteristics beyond mere species identification.