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- Transcriptional coregulation in cis around a contact insulation site revealed by single-molecule microscopy
Transcriptional coregulation in cis around a contact insulation site revealed by single-molecule microscopy
Auteurs
Maciej A. Kerlin, Ilham Aboulfath-Ladid, Julia Roensch, Chloé Jaubert, Aude Battistella, Kyra J. E. Borgman, Antoine Coulon
Résumé
Abstract
Chromosome conformation in mammals is closely related to gene regulation. Within topologically associating domains, where genomic contacts are enriched, genes tend to show correlated expression across tissues and conditions, suggesting domain-wide mechanisms coregulating multiple genes, such as enhancer sharing or local histone mark spreading. At the single-cell level, where transcription occurs in sporadic bursts, transcriptional coordination has been observed between proximal genes, but how the local folding of mammalian chromosomes influences gene coregulation
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