Séminaire Cell Biology Series
27 septembre
2022

Mechanical and biochemical signals influencing dendritic cell functions.

Le 27 septembre - 11h-23h
Centre de recherche - Paris - Amphithéâtre Marie Curie
Pavillon Curie, 11 rue Pierre & Marie Curie, Paris 5ème
Description

Specialized leukocytes called dendritic cells (DCs) are key regulators of immune responses. They crawl within tissues patrolling for pathogens or aberrant cells. Upon danger recognition, DCs mature and migrate to lymph nodes to initiate immune responses. During their life-cycle, DCs experience multiple, elastically diverse microenvironments as well as different mechanical stimuli, such as spatial constraints, fluid shear stress and topological cues. These mechanical signals have to be combined with biochemical signals such as cytokines and lipid mediators (e.g.: prostaglandin E2, PGE2).

This lecture will present bioimaging-driven novel insights into fundamental biophysical mechanisms regulating DC response to tissue stiffness as well as our efforts to unravel the importance of PGE2 receptor usage in modulating DC differentiation and activation.

Orateurs
Alexandra
Cambi
PhD, Professor of Cell Biology|
| Chair | Dept. Cell Biology| | RIMLS | Radboudumc
Organisateur(s)
Philippe
Chavrier
Institut Curie
Invité(es) par
Philippe
Chavrier
Institut Curie
Christophe
Lamaze
Institut Curie
Contact
Christophe
Lamaze
Institut Curie