SOPHIE BOMBARD

Docteur

Recherche - Orsay

Spécialités / domaines

Biologie et chimie des radiations, signalisation cellulaire et cancer

Fonctions au sein de l'Institut Curie :

Chercheur permanent

Médicaments et sondes pour les structures secondaires des acides nucléiques
Unité : Chimie et Modélisation pour la Biologie du Cancer (UMR9187 / U1196)

Publications

2024

Light‐Activatable Photocaged UNC2025 for Triggering TAM Kinase Inhibition in Bladder Cancer

ChemBioChem

Chloé Breton-Patient, Sébastien Billotte, Patricia Duchambon, Gaëlle Fontaine, Sophie Bombard, Sandrine Piguel

(2024 fév 16)

2023

Unprecedented reactivity of polyamines with aldehydic DNA modifications: structural determinants of reactivity, characterization and enzymatic stability of adducts

Nucleic Acids Research

Eka Putra Gusti Ngurah Putu, Laurent Cattiaux, Thomas Lavergne, Yves Pommier, Sophie Bombard, Anton Granzhan

(2023 oct 18)

2023

Anti-Cancer and Radio-Sensitizing Properties of New Bimetallic (<i>N</i>-Heterocyclic Carbene)-Amine-Pt(II) Complexes

Journal of Medicinal Chemistry

Tao Jia, Oumar Diane, Deepanjan Ghosh, Myriem Skander, Gaelle Fontaine, Pascal Retailleau, Joël Poupon, Jérôme Bignon, Ytabelle Maga Moulai Siasia, Vincent Servajean, Nathalie Hue, Jean-François Betzer, Angela Marinetti, Sophie Bombard

(2023 mai 16)

2022

Photoactivatable V‐Shaped Bifunctional Quinone Methide Precursors as a New Class of Selective G‐quadruplex Alkylating Agents

Chemistry – A European Journal

Alberto Lena, Alessandra Benassi, Michele Stasi, Christine Saint-Pierre, Mauro Freccero, Didier Gasparutto, Sophie Bombard, Filippo Doria, Daniela Verga

(2022 juin 21)

2022

Acridine–O6-benzylguanine hybrids: Synthesis, DNA binding, MGMT inhibition and antiproliferative activity

European Journal of Medicinal Chemistry

Jaime Franco Pinto, Alexandra Fillion, Patricia Duchambon, Sophie Bombard, Anton Granzhan

(2022 jan 01)

2021

Photoactivatable Small‐Molecule Inhibitors for Light‐Controlled TAM Kinase Activity

ChemPhotoChem

Julie Le Bescont, Liliane Mouawad, Thomas Boddaert, Sophie Bombard, Sandrine Piguel

(2021 nov 01)

2021

Pt-ttpy, a G-quadruplex binding platinum complex, induces telomere dysfunction and G-rich regions DNA damage

Metallomics

Samar Ali, Emilia Puig Lombardi, Deepanjan Ghosh, Tao Jia, Géraldine Vitry, Lina Saker, Joël Poupon, Marie-Paule Teulade-Fichou, Alain Nicolas, Arturo Londono-Vallejo, Sophie Bombard

(2021 juin 12)

2020

Nucleolin Discriminates Drastically between Long-Loop and Short-Loop Quadruplexes

Biochemistry

Abhijit Saha, Patricia Duchambon, Vanessa Masson, Damarys Loew, Sophie Bombard, Marie-Paule Teulade-Fichou

(2020 Mar 31)

2019

Interaction of Functionalized Naphthalenophanes with Abasic Sites in DNA: DNA Cleavage, DNA Cleavage Inhibition, and Formation of Ligand–DNA Adducts

Chemistry – A European Journal

Coralie Caron, Xuan N. T. Duong, Régis Guillot, Sophie Bombard, Anton Granzhan

(2019 fév 06)

2019

Selectivity of Terpyridine Platinum Anticancer Drugs for G-quadruplex DNA

Molecules

Elodie Morel, Claire Beauvineau, Delphine Naud-Martin, Corinne Landras-Guetta, Daniela Verga, Deepanjan Ghosh, Sylvain Achelle, Florence Mahuteau-Betzer, Sophie Bombard, Marie-Paule Teulade-Fichou

(2019 jan 23)