Unité

Chimie et Modélisation pour la Biologie du Cancer (UMR9187 / U1196)

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UMR9187/U1196 - retraite - 2023-04-18

Retraite scientifique de l'UMR9187/U1196 au Domaine Saint-Paul à Saint-Rémy-lès-Chevreuse le 18 avril 2023

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Unité
Chimie et Modélisation pour la Biologie du Cancer (UMR9187 / U1196)

L’activité centrale de l’unité CMBC est de développer des petites molécules pour sonder et contrôler les activités biologiques de cibles impliquées dans le cancer. Ce sont des structures non canoniques d’acides nucléiques (G-quadruplexes, sites abasiques, …) et des protéines (Kinases TAM, acides nucléiques non B interagissant avec des protéines, …).

Chiffres-clés
10
brevets déposés sur les 5 dernières années
1
molécule en phase clinique pour la rectocolite hémorragique (phase 3 prévue fin 2021)
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Événements scientifiques
9 fév
2024
Séminaire
14h-23h
Centre de recherche - Orsay - Amphithéâtre du Bâtiment 111
Plant-derived chemical probes and leads that target OSBP protein, a key player in cholesterol homeostasis
Living organisms like plants, produce specialized metabolites to defend themselves against predators or pests.  They can be viewed as privileged structures pre-validated by Nature and are invaluable starting points for drug discovery programs and probe synthesis. This seminar will focus on schweinfurthins and their derivatives, compounds with promising anti-cancer properties that target OSBP
8 déc
2023
Séminaire Orsay series
11h-23h
Centre de recherche - Orsay - Amphithéâtre du Bâtiment 111
Illuminating the Path: A ChemBio Toolbox for Biological Processes
Life is highly dynamic relaying on a myriad of carefully orchestrated processes with strict spatial and temporal control. To decipher cellular functions and, in turn, address complex biological questions is necessary to have precise control. In my group, we pursue such the dream of achieving a molecularly precise understanding of biology to address the problems arising from misregulation. For this
26 juin
2023
Séminaire
12h-12h
Centre de recherche - Orsay - Amphithéâtre du Bâtiment 111
Chemical Biology Tools to unravel biological functions of nucleic acids secondary structures
DNA and RNA containing runs of 3 or 4 adjacent guanines may spontaneously arrange into four-stranded DNA supramolecular structures called G-quadruplexes (G4). These non-canonical structures are likely to form in G-rich regions throughout the genome and thus are assumed to have functional roles in key biological processes, such as replication, transcription, repair, and recombination, and thereby t
26 juin
2023
Séminaire
11h-12h
Centre de recherche - Orsay - Amphithéâtre du Bâtiment 111
Proximity-induced targeted RNA degradation for mapping RNA modifications and drugging SARS-CoV-2 genome
Using small molecules to modulate RNA stability is an emerging paradigm which holds promise to greatly expand the space of druggable biomolecules. In this talk I will present two divergent applications of small molecule-induced targeted RNA degradation. Firstly, we devised a click chemistry- and degradation-based method to map RNA modifications, meCLICK-Seq. This unorthodox approach enabled discov
26 juin
2023
Séminaire
11h-11h
Centre de recherche - Orsay - Amphithéâtre du Bâtiment 111
Molecular Engineering of Light-Activated Probes for Precision Diagnostics, Therapy, and Opto-Biology
Probing living systems with light-responsive molecules has unlocked new perspectives on the study of biological targets, but also on clinical diagnostics and targeted therapies. However, further progress in opto-biology requires a level of precision that standard, non-specific photo-activation cannot provide. The challenge therefore lies in the development of a toolbox of light-activated probes ab
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