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- Endosomal trafficking defects alter neural progenitor proliferation and cause microcephaly
Endosomal trafficking defects alter neural progenitor proliferation and cause microcephaly
Auteurs
Jacopo A. Carpentieri, Amandine Di Cicco, Marusa Lampic, David Andreau, Laurence Del Maestro, Fatima El Marjou, Laure Coquand, Nadia Bahi-Buisson, Jean-Baptiste Brault, Alexandre D. Baffet
Résumé
Abstract
Primary microcephaly and megalencephaly are severe brain malformations defined by reduced and increased brain size, respectively. Whether these two pathologies arise from related alterations at the molecular level is unclear. Microcephaly has been largely associated with centrosomal defects, leading to cell death. Here, we investigate the consequences of
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Membres

AMANDINE DI CICCO
Ingénieur d'études
JEAN-BAPTISTE BRAULT
Maître de conférences Sorbonne Université