Epigenetics: from pluripotent stem cells to ancient DNA

8 octobre - 11h00 - 23h59

Centre de recherche - Paris

Amphithéâtre Hélène Martel-Massignac (BDD)

11 rue Pierre et Marie Curie - 75005 Paris

Description

Pluripotent embryonic stem cells (ESCs) are characterized by a unique, globally decondensed, chromatin structure. In the first and main part will describe our endogenously-tagged fluorescent-fusion protein libraries in mouse ESCs, which we used to screen for potential regulators of pluripotency and early ESC differentiation. I will discuss two prominent hits which we identified: a nuclear protein, SET, involved in regulation of pluripotency and early development, and a cytoplasmic protein, CAPRIN1, involved in degrading developmental RNA transcripts during early ESC differentiation.

 

In the second part, I will more briefly discuss our recent work on paleo-epigenetics, where we are reconstructing DNA methylation in ancient DNA. This technique allows us to identify differentially methylated genes between modern and archaic humans, and more recently, between pre- and post-Neolithic societies.

Orateurs

Eran Meshorer

Department of Genetics, The Institute of Life Science & The Edmond and Lily Safra Center for Brain Sciences (ELSC), The Hebrew University of Jerusalem

Invité(es) par

Geneviève Almouzni

Institut Curie

Une question sur le séminaire ?

Geneviève Almouzni

genevieve.almouzni@curie.fr