Single cell and spatial technologies to study retinoblastoma cells population and their dynamics

8th Spatial Transcriptomics Odyssey Seminar :

For the 8th session of the seminar, we are hosting Clément Hua from the Molecular Oncology Team (UMR144). Retinoblastoma  is the most common intraocular malignancy afflicting children. Our research group has shown that retinoblastoma presents two subtypes associated with different molecular and clinical features including a strong intra-tumoral heterogeneity among subtype 2 tumors. By using single-cell and spatial technologies to study cell subpopulations and their dynamics, our analyses aims to better understand the origin and heterogeneity of retinoblastoma.  To fully benefit from the complementarity of these two technologies, some challenges need to be addressed, such as making comparable the results obtained with these two modalities, and eventually integrating the data.

The scope of this seminar is to share how people working with spatial transcriptomics data are navigating them, from technological advances to the developpement of computational tools, as well as to exchange news in the field through a journal club. It thus encourages researchers from different teams to come and share their work and their questions but also receive valuable input from pairs working with similar problematics.The seminar will take place physically at Institute Curie Paris. We encourage you to come onsite to have an interactive discussion and visioconférence is made available.