In situ structural mechanism of Epothilone B-induced CNS axon regeneration

Neurons in the Central Nervous System (CNS) often struggle to regenerate following traumatic brain injury, with the underlying molecular mechanisms largely unknown. We developed a cryo-electron tomography/light microscopy pipeline to simulate axonal injury and regeneration on electron microscope (EM) grids. I will discuss how Epothilone B (EpoB), a chemical compound, alters intracellular organization to promote neuron regeneration and facilitate repair.

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