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- Unraveling tumor initiation and progression in live animals through cutting-edge intravital microscopy
Unraveling tumor initiation and progression in live animals through cutting-edge intravital microscopy
Centre de recherche - Paris
Amphithéâtre Marie Curie
Pavillon Curie, 11 rue Pierre & Marie Curie, Paris 5ème
Description
Abstract:Â Â
Using cutting-edge intravital microscopy we have investigated the carcinogen-driven initiation and progression of head and neck squamous cell carcinoma. We imaged, on a weekly basis, multiple cancerous lesions for over 24-26 weeks and discovered that within the same animal they either progress to a malignant state (20%), halt their progression (40%), or completely regress (40%). Combining this approach with a i) battery of genetically engineered mouse models, ii) newly developed machine learning-based quantitative methods, and iii) spatial multi omics, we have begun to unravel the key role that cellular metabolism and myeloid cells play in determining the fate of the lesions.
Orateurs
Roberto Weigert
Invité(es) par
Ludger Johannes
Institut Curie
Une question sur le séminaire ?
Ludger Johannes