Why neuroblastoma occurs in the adrenal gland? Cell fate decision implication in pediatric cancer

8 juillet - 09h30 - 10h30

Centre de recherche - Paris

Amphithéâtre Marie Curie

Pavillon Curie, 11 rue Pierre & Marie Curie, Paris 5ème

Description

Neuroblastoma is one of the deadliest pediatric malignancies, which is composed of sympathetic neuroblasts and most often occurs in the adrenal gland. However, for the adrenal gland, the neuroblasts are not a typical cell type. The medullary region of the adrenal gland is composed mainly of chromaffin cells. Chromaffin cells and sympathetic neuroblasts share the developmental lineage however, the exact point at which the vulnerability for neuroblastoma emerges in the development remains elusive.

In my talk for the Nuclear Dynamics Seminar, I will describe how single-cell transcriptomic methods provide unprecedented resolution into the developmental dynamics and help to reveal specific points of neuroblastoma vulnerability that arise during human development. I will provide insights into how single-cell atlases can be used to generate hypotheses about the roles of developmental transitions and how such transitions can be investigated for implication in pediatric tumorigenesis. 

Organisateurs

Caroline Audouin

Institut Curie

Orateurs

Kameneva Polina

St. Anna ChildrenÂ’s Cancer Research Institute (CCRI), Vienna, Austria

Invité(es) par

Anna Shmakova

Institut Curie

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