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- Why neuroblastoma occurs in the adrenal gland? Cell fate decision implication in pediatric cancer
Why neuroblastoma occurs in the adrenal gland? Cell fate decision implication in pediatric cancer
Centre de recherche - Paris
Amphithéâtre Marie Curie
Pavillon Curie, 11 rue Pierre & Marie Curie, Paris 5ème
Description
Neuroblastoma is one of the deadliest pediatric malignancies, which is composed of sympathetic neuroblasts and most often occurs in the adrenal gland. However, for the adrenal gland, the neuroblasts are not a typical cell type. The medullary region of the adrenal gland is composed mainly of chromaffin cells. Chromaffin cells and sympathetic neuroblasts share the developmental lineage however, the exact point at which the vulnerability for neuroblastoma emerges in the development remains elusive.
In my talk for the Nuclear Dynamics Seminar, I will describe how single-cell transcriptomic methods provide unprecedented resolution into the developmental dynamics and help to reveal specific points of neuroblastoma vulnerability that arise during human development. I will provide insights into how single-cell atlases can be used to generate hypotheses about the roles of developmental transitions and how such transitions can be investigated for implication in pediatric tumorigenesis.Â
Organisateurs
Caroline Audouin
Institut Curie
Orateurs
Kameneva Polina
St. Anna ChildrenÂ’s Cancer Research Institute (CCRI), Vienna, Austria
Invité(es) par
Anna Shmakova
Institut Curie