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Temporary contract
Paris

Bioinformatician engineer in spatial transcriptomics data analysis

  • Centre de Recherche

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(EN) The Institut Curie, a key player in the fight against cancer, combines a hospital and a research center with over 1,000 staff members. Its goal is to improve diagnosis, prognosis, and treatments through a continuum between basic research and innovation. The position is funded by the Institute of Women’s Cancers, an interdisciplinary initiative aiming for comprehensive care of breast and gynecological cancers, recognized as a University Hospital Institute (IHU) under the France 2030 program.

Goal of the position

The goal of the position is to develop computational pipelines for spatial transcriptomics analysis using Visium HD. These pipelines will be designed to characterize the composition and evolution of the tumor microenvironment in relation to age, treatment response, and cancer progression. A particular emphasis will be placed on CAF subpopulations and their interactions with cancer, immune, and endothelial cells.

As part of your responsibilities, you will:

  • Develop, test, and implement computational tools for spatial transcriptomics analysis.

  • Process and analyze multidimensional imaging and spatial data (stitching, segmentation, quantification, cell clustering).

  • Work with researchers to design and apply image-processing algorithms for high-resolution microscopy datasets.

  • Validate and optimize computational pipelines for large-scale data integration.

  • Provide training and tutorials to facilitate the use of developed tools.

  • Deliver publication-grade results, reports, and material.

  • Follow the Good Practices of the Institut Curie Bioinformatic Cluster

All our opportunities are open to individuals with disabilities.

Candidate Profile

Qualifications & Experience

  • Master or Ph.D. in Computational Biology, Bioinformatics, or a related field.

  • Proficiency in programming languages such as Python and R

  • Good knowledge in statistics and machine learning (IA/Deep learning is a plus) 

  • Great interest in biology, oncology and/or immunology 

  • Previous experience with single cell RNA-seq and/or spatial transcriptomics data analyses is a plus 

  • Ability to communicate scientific results in a clear and didactic manner

  • Familiarity with high-performance computing (HPC) environments.

  • Excellent interpersonal communication, teamwork and organizational skills

  • Ability to self-learn and a problem-solving approach to work

  • Flexibility and organizational skills to advance several projects in parallel.

  • Fluency in English (written and spoken).

Additional Information

  • Location: flexible work location at Institut Curie, rue d’Ulm, 75005 Paris and remotely.

  • Contract: 18-month fixed-term position, with the possibility of a 18-month extension based on performance (CDD).

  • Start date: As soon as possible.

  • Working time: full time.

  • Remuneration: according to the current grids

  • Benefits: collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance

 

How to Apply

Interested candidates should send their CV, cover letter, and contact information for references

 

The Institut Curie is an inclusive and equal opportunity employer and upholds strict standards in research integrity.

https://euraxess.ec.europa.eu/sites/default/files/brochures/eur_21620_en-fr.pdf