Bioinformatics Research Engineer Position - Omics Data Analysis(M/F)

Centre de Recherche

Partager cette offre :

Copié

Postuler

Institut Curie is a major player in the research and fight against cancer. It consists of a Hospital group and a Research Center of more than 1000 employees with a strong international representativeness.

The objective of the Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient.

Laboratory

Chromatin Dynamics

Recent publications:

· Renaud-Pageot, C. & Almouzni, G. Tipping the balance in histone supply puts genome stability at stake. Embo j 43, 2091-2093 (2024).

· Mendiratta, S. et al. Regulation of replicative histone RNA metabolism by the histone chaperone ASF1. Mol Cell 84, 791-801.e6 (2024).

· Karagyozova, T. & Almouzni, G. Replicating chromatin in the nucleus: A histone variant perspective. Curr Opin Cell Biol 89, 102397 (2024).

· Gatto, A., Forest, A., Quivy, J.-P. & Almouzni, G. HIRA-dependent boundaries between H3 variants shape early replication in mammals. Molecular Cell (2022).

· Delaney, K., Weiss, N. & Almouzni, G. The cell-cycle choreography of H3 variants shapes the genome. Mol Cell 83, 3773-3786 (2023).

The project

The candidate will contribute to the bioinformatic analysis of high-throughput omics data generated across multiple molecular and cellular biology research projects within the laboratory. This includes the processing, exploration, and interpretation of omics datasets (including RNA-seq, ChIP-seq, and ATAC-seq) in close collaboration with experimental teams.

Additional responsibilities include:

Designing and implementing analysis pipelines tailored to specific data types and biological hypotheses,
Generating data visualizations, reports, and summaries suitable for interpretation by biologists,
Contributing to the dissemination of results through publications, figure generation, and data deposition.

Training and Skills required

The candidate should hold a PhD

The candidate should have at least 5 years experience in bioinformatic analysis

The candidate should be able to perform data mining from various databases (genomics, proteomics, pathologies, organisms evolution) and be able to combine datasets from available datasets and produced omic data in the host team to generate dedicated data sets for research projects in the host team

The candidate should have expertise and experience in multiomics analysis from bulk and single cell data sets. This includes:

· gene expression analysis s including transcripts identification and splicing analysis

· ChIP-Seq analysis

· Chromatin chromatin organization (ATAc-Seq, nuclease sensitivity, Hi-C)

Abilities

Deep understanding of biological processes associated with epigenetics, chromatin organization and dynamics ans spatial organization of the genome in mamalian cells

The candidate should be autonomous and in permanent liase with biologists of the team to report and discuss findings

All our opportunities are open to people with disabilities

Contract information

Type of contract: CDD

Starting date: position available immediately

Duration: 9 months

Working time: full time

Remuneration: according to the current grids

Benefits: Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance

Location of the position: Paris

Reference:

Contact

Please send your CV, letter of motivation and 2 references

Publication date: 06/11/2025

Deadline for application: until filled

Institut Curie is an inclusive, equal opportunity employer and is dedicated to the highest standards of research integrity.

https://euraxess.ec.europa.eu/sites/default/files/brochures/eur_21620_en-fr.pdf