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- 3 tera-basepairs as a fundamental limit for robust DNA replication
3 tera-basepairs as a fundamental limit for robust DNA replication
Auteurs
M Al Mamun, L Albergante, J J Blow, T J Newman
Résumé
Abstract
In order to maintain functional robustness and species integrity, organisms must ensure high fidelity of the genome duplication process. This is particularly true during early development, where cell division is often occurring both rapidly and coherently. By studying the extreme limits of suppressing DNA replication failure due to double fork stall errors, we uncover a fundamental constant that describes a trade-off between genome size and architectural complexity of the developing organism. This constant has the approximate value