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- Abstract 2417: Oncogenic properties shared by all Snail family members
Abstract 2417: Oncogenic properties shared by all Snail family members
Auteurs
Baptiste Gras, Christelle Chassot, Alain Puisieux, Stéphane Ansieau
Résumé
Abstract
The epithelial to mesenchymal transition (EMT) is a latent embryonic process promoting cell migration by transiently affording epithelial cells a mesenchymal phenotype, motility and a survival advantage. The inappropriate activation of this program in adult cells is associated with several pathologies including tumor development where EMT promotes cancer cell dissemination and multidrug resistance development. We have recently demonstrated that EMT-inducers, beyond their prometastatic potential, facilitate the malignant transformation of human mammary epithelial cells in vitro and promote breast carcinogenesis in vivo. Although their ability to alleviate senescence and apoptosis failsafe program induction unquestionably contributes to their oncogenic potentials, we sought to investigate whether EMT inducers share additional properties. To this end, the activities of all three Snail members were examined. Likewise SNAI1 and SNAI2, SNAI3 expression is aberrantly activated in cancers, especially in mammary carcinomas. Ectopic expression of all three proteins in mammary epithelial cells induces their commitment into EMT, provides cells with a survival advantage in low adherent conditions and promotes their neoplastic transformation, with a similar gradient of efficiencies. Interestingly, this efficiency parallels with their ability to upregulate intracellular signaling pathways. We will update on the progress of our work aimed at understanding how these dysregulations impact on their oncogenic and prometastatic potential.
Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2417. doi:1538-7445.AM2012-2417
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