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- Architecture and migration of an epithelium on a cylindrical wire
Architecture and migration of an epithelium on a cylindrical wire
Auteurs
Hannah G. Yevick, Guillaume Duclos, Isabelle Bonnet, Pascal Silberzan
Résumé
Significance
Cell sheets often organize in tubular structures, for example, in the kidney. Also, cells from epithelial tumors are known to wrap around vessels or muscle fibers as they migrate collectively. By plating cells on thin glass wires, we mimic these physiological conditions in vitro and show that high curvature favors cell detachment at the front edge. This switch from collective to individual migration may reproduce features often observed in cancer invasion. High curvature also induces a circumferential organization of the actin cytoskeleton reminiscent of in vivo embryonic morphogenesis situations where tissues develop on a cylindrical template. Finally, monolayer migration is halted at submicron radii, and the tissue reconfigures into hollow cysts at its leading tip.
Membres

PASCAL SILBERZAN
Directeur de recherche CNRS