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- Aryl hydrocarbon receptor–dependent enrichment of a megakaryocytic precursor with a high potential to produce proplatelets
Aryl hydrocarbon receptor–dependent enrichment of a megakaryocytic precursor with a high potential to produce proplatelets
Auteurs
Catherine Strassel, Nathalie Brouard, Lea Mallo, Nicolas Receveur, Pierre Mangin, Anita Eckly, Ivan Bieche, Karin Tarte, Christian Gachet, François Lanza
Résumé
Key Points
Emergence of a CD34+CD41low population with a high capacity to generate proplatelet-producing MKs and functional platelet-like elements. Platelet production is inversely correlated to CYP1B1 expression, a target of the aryl hydrocarbon receptor.