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- αTAT1 controls longitudinal spreading of acetylation marks from open microtubules extremities
αTAT1 controls longitudinal spreading of acetylation marks from open microtubules extremities
Auteurs
Nathalie Ly, Nadia Elkhatib, Enzo Bresteau, Olivier Piétrement, Mehdi Khaled, Maria M. Magiera, Carsten Janke, Eric Le Cam, Andrew D. Rutenberg, Guillaume Montagnac
Résumé
Abstract
Acetylation of the lysine 40 of α-tubulin (K40) is a post-translational modification occurring in the lumen of microtubules (MTs) and is controlled by the α-tubulin acetyl-transferase αTAT1. How αTAT1 accesses the lumen and acetylates α-tubulin there has been an open question. Here, we report that acetylation starts at open ends of MTs and progressively spreads longitudinally from there. We observed acetylation marks at the open ends of
Membres

MAGDA MAGIERA
Chargé de recherche CNRS