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- Chemical Inhibition of NAT10 Corrects Defects of Laminopathic Cells
Chemical Inhibition of NAT10 Corrects Defects of Laminopathic Cells
Auteurs
Delphine Larrieu, Sébastien Britton, Mukerrem Demir, Raphaël Rodriguez, Stephen P. Jackson
Résumé
Remodelin Nuclear Defects
Deregulation of A-type lamin proteins leads to disorganization of chromatin structure and misshapen nuclei, which are believed to underlie the pathologies of various human diseases, including the premature aging disorder Hutchinson Gilford progeria syndrome (HGPS) and various cancers.
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