Control of MT1-MMP transport by atypical PKC during breast-cancer progression

Proceedings of the National Academy of Sciences
C. Rosse, C. Lodillinsky, L. Fuhrmann, M. Nourieh, P. Monteiro, M. Irondelle, E. Lagoutte, S. Vacher, F. Waharte, P. Paul-Gilloteaux, M. Romao, L. Sengmanivong, M. Linch, J. van Lint, G. Raposo, A. Vincent-Salomon, I. Bieche, P. J. Parker, P. Chavrier
DOI
10.1073/pnas.1400749111
Abstract

Significance
We characterize a mechanism through which the polarity protein atypical PKCι controls invasion and matrix remodeling by tumor cells by regulating endosome-to-plasma membrane traffic of the membrane type 1-matrix metalloproteinase (MT1-MMP) in breast-cancer cells. Further analysis shows that atypical PKCι and MT1-MMP are co–up-regulated in hormone receptor-negative breast tumors in association with higher risk of metastasis. These findings provide previously unidentified avenues for the design of therapeutic interventions.

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