Control of MT1-MMP transport by atypical PKC during breast-cancer progression

Nom de la revue
Proceedings of the National Academy of Sciences
C. Rosse, C. Lodillinsky, L. Fuhrmann, M. Nourieh, P. Monteiro, M. Irondelle, E. Lagoutte, S. Vacher, F. Waharte, P. Paul-Gilloteaux, M. Romao, L. Sengmanivong, M. Linch, J. van Lint, G. Raposo, A. Vincent-Salomon, I. Bieche, P. J. Parker, P. Chavrier

We characterize a mechanism through which the polarity protein atypical PKCι controls invasion and matrix remodeling by tumor cells by regulating endosome-to-plasma membrane traffic of the membrane type 1-matrix metalloproteinase (MT1-MMP) in breast-cancer cells. Further analysis shows that atypical PKCι and MT1-MMP are co–up-regulated in hormone receptor-negative breast tumors in association with higher risk of metastasis. These findings provide previously unidentified avenues for the design of therapeutic interventions.