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- Cortical instability drives periodic supracellular actin pattern formation in epithelial tubes
Cortical instability drives periodic supracellular actin pattern formation in epithelial tubes
Auteurs
Edouard Hannezo, Bo Dong, Pierre Recho, Jean-François Joanny, Shigeo Hayashi
Résumé
Significance
Robust pattern formation is a ubiquitous question of developmental biology. In 1952, Turing proposed in a seminal paper that this could be achieved by a hydrodynamical instability of two diffusing species reacting with each other, but direct experimental evidence of how a mechanism is implemented biologically is still lacking. In this paper, we show by a combination of experiment and theory that the actin cytoskeleton, one of the main force-producing mechanisms in biology, has the property to self-organize into regular supracellular patterns in vivo in