ESCRT Machinery Is Required for Plasma Membrane Repair
Nom de la revue
Science
Abstract
ESCRT Your Wound Away
The ESCRT (endosomal sorting complex required for transport) protein complex plays a role in budding into multivesicular bodies, in cytokinesis, and in HIV budding. Now,
Jimenez
et al.
(p.
10.1126/science.1247136
, published online 30 January) propose a role for ESCRT proteins in wound repair at the plasma membrane. In vivo imaging, modeling, and electron microscopy were used to reveal how the ESCRTs participate in a rapid energy-independent, calcium-dependent, membrane-shedding process at the plasma membrane that reseals small wounds caused by toxins or laser treatment.