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- In vivo genome-wide CRISPR screens identify SOCS1 as intrinsic checkpoint of CD4 <sup>+</sup> T <sub>H</sub> 1 cell response
In vivo genome-wide CRISPR screens identify SOCS1 as intrinsic checkpoint of CD4 <sup>+</sup> T <sub>H</sub> 1 cell response
Auteurs
Aurélien Sutra Del Galy, Silvia Menegatti, Jaime Fuentealba, Francesca Lucibello, Laetitia Perrin, Julie Helft, Aurélie Darbois, Michael Saitakis, Jimena Tosello, Derek Rookhuizen, Marc Deloger, Pierre Gestraud, Gérard Socié, Sebastian Amigorena, Olivier Lantz, Laurie Menger
Résumé
Inactivation of SOCS1 optimizes adoptive T cell therapy including human CAR-T cell composition and efficacy.
Equipes
Membres
SEBASTIAN AMIGORENA
Directeur de recherche CNRS
PIERRE GESTRAUD
Ingénieur de recherche