La voie de signalisation Notch dans les cellules souches et les tumeurs

In spite of the great advances of developmental biology in the past years, the mechanisms underlying morphogenesis and homeostasis of adult organs remain only superficially understood. Somatic stem cells are critical players during developmental growth and for maintaining adult tissue homeostasis.

The main focus of our research is understanding how tissue-specific stem cells engage in differentiation while retaining self-renewal potential and plasticity.