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Unité
Génétique et biologie du développement (UMR3215 / U934)

L’unité de recherche « Génétique et Biologie du Développement » de l’Institut Curie se compose de neuf équipes abordant des questions fondamentales relatives au développement des organismes et à ses dérèglements pathologiques.

Chiffres-clés
16
publications en 2020
3
ERC en cours en 2020
24
Doctorants en thèse en 2020
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Événements scientifiques
25 avr
2024
Séminaire
16h-23h
Centre de recherche - Paris - Amphithéâtre Hélène Martel-Massignac (BDD)
Mechanics of Neural Crest Development: From Induction to Migration and Differentiation
The neural crest is an embryonic cell population whose migratory behavior has been likened to cancer invasion during metastasis. Neural crests differentiate into a wide array of cell types, including muscle, cartilage, bones, melanocytes, neurons, and glia. Although the role of mechanical cues has been demonstrated in the migration and differentiation of neural crest cells, little is known about w
11 avr
2024
Séminaire institutionnel "Mayent - Rothschild"
10h-23h
Centre de recherche - Paris - Amphithéâtre Hélène Martel-Massignac (BDD)
Mechanism of receptor choice in the olfactory system of ants
Bogdan Sieriebriennikov1,2, Hua Yan2 and Claude Desplan1

(1) NYU Biology, New York

(2) University of Florida, Gainesville

In both flies and vertebrates, smell is perceived by olfactory sensory neurons (OSNs) that rely on the expression of a single odorant receptor (Or) gene per cell to discriminate between odors. Flies have few Or genes (~60), while mammals have many (>1,000 in mice),
28 Mar
2024
Séminaire
10h-23h
Centre de recherche - Paris - Amphithéâtre Hélène Martel-Massignac (BDD)
Spatiotemporal models of mammalian development: An epigeneticist’s dream or nightmare?
My research group aims to address the fundamental challenge of understanding how multicellular organisms achieve variation despite cells having identical genetic information. The development of a single fertilized egg into a complete mammalian embryo is an especially beautiful embodiment of this problem. During this process, cellular differentiation is defined by the capacity of the cell ensemble
29 fév
2024
Séminaire
10h-23h
Centre de recherche - Paris - Amphithéâtre Marie Curie
Metabolism of neural stem cell-niche interactions
Metabolism of neural stem cell – niche interactions

While almost all eukaryotic cells require mitochondrial energy production, not all cells and tissues are equally susceptible to mitochondrial disease. In our lab, we mainly study how mitochondrial dysfunction and mutations in the mitochondrial genome affect neural stem cell (NSC) behaviour in Drosophila and mouse. Our
21 Sep
2023
Séminaire Keynote BDD
09h-23h
Centre de recherche - Paris - Amphithéâtre Marie Curie
A Circuit Approach to Understand Aging
Uri Alon´s laboratory is focused on several aspects of systems biology, which intersect well with fundamental biological questions addressed by different groups in our unit, and span from investigating gene expression regulation, tissue homeostasis and morphogenesis, network motifs and the design principles of biological circuits. By combining computational biology, mathematical modeling and
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