Postdoctoral Position in oncology (M/F)

Laboratory

The Pouponnot’s team investigates signaling pathways and their impact on transcription factors in cancer, employing a range of biochemical and functional experimental approaches both in vitro and in vivo. We have extensive expertise in the use of mouse models and have developed a strong research focus on pediatric brain tumors, particularly medulloblastoma, as demonstrated in our publications (Garancher et al., Cancer Cell, 2018; Morabito et al., EMBO Mol Med, 2019). Our group has established genetically engineered mouse models, patient-derived xenografts, and advanced radiobiology tools to study cancer, including pediatric brain tumors, especially medulloblastoma (MB). Current research efforts are focused on elucidating mechanisms of treatment resistance—especially to radiotherapy—and identifying actionable molecular vulnerabilities in pediatric brain cancers.

https://curie.fr/equipe/eychene_pouponnot

The project

Medulloblastoma (MB) is a pediatric tumor of the cerebellum, which represents the most frequent malignant brain tumor in childhood. It is classified into four subgroups: WNT, SHH, group 3 (G3) and group 4. G3 has the poorest prognosis and is associated with a high rate of metastasis and a high probability of relapse. Mechanisms and transcription factors (TFs) that drive its initiation, maintenance, therapeutic resistance and metastatic potential are poorly characterized. Here, we propose to investigate the role of a TF recently identified as a major regulator of the G3 signature. The project focuses on the understanding of its role in G3-MB at the molecular level (RNAseq, ChIPSeq, CRISPR Screen (TF network)…), cellular level (proliferation, protection against apoptosis, migration…) and in tumor progression (in vivo orthotopic grafting).

Contraints (to be cancelled if not necessary)

-        work outside regular working days (in vivo experiments)