RAPHAEL CECCALDI

Docteur,

Chargé de recherche Inserm

Recherche - Paris

Spécialités / domaines

Biologie

Fonctions au sein de l'Institut Curie :

Chef d'équipe de recherche

Mécanismes alternatifs de réparation de l'ADN dans les cancers
Unité : Cancer, Hétérogénéité, Instabilité et Plasticité - CHIP (U830)

Publications

2023

DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A/C

Molecular Cell

Marton Tibor Kovacs, Marie Vallette, Pauline Wiertsema, Florent Dingli, Damarys Loew, Guilherme Pedreira de Freitas Nader, Matthieu Piel, Raphael Ceccaldi

(2023 oct 01)

2023

Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis

Nature

Camille Gelot, Marton Tibor Kovacs, Simona Miron, Emilie Mylne, Alexis Haan, Liza Boeffard-Dosierre, Rania Ghouil, Tatiana Popova, Florent Dingli, Damarys Loew, Josée Guirouilh-Barbat, Elaine Del Nery, Sophie Zinn-Justin, Raphael Ceccaldi

(2023 Sep 14)

2021

A first-in-class polymerase theta inhibitor selectively targets homologous-recombination-deficient tumors

Nature Cancer

Jia Zhou, Camille Gelot, Constantia Pantelidou, Adam Li, Hatice Yücel, Rachel E. Davis, Anniina Färkkilä, Bose Kochupurakkal, Aleem Syed, Geoffrey I. Shapiro, John A. Tainer, Brian S. J. Blagg, Raphael Ceccaldi, Alan D. D’Andrea

(2021 juin 01)

2018

CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress

Molecular Cell

Sara Przetocka, Antonio Porro, Hella A. Bolck, Christina Walker, Aleksandra Lezaja, Anika Trenner, Christine von Aesch, Sarah-Felicitas Himmels, Alan D. D’Andrea, Raphael Ceccaldi, Matthias Altmeyer, Alessandro A. Sartori

(2018 nov 01)

2017

EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation

Nature Cell Biology

Beatrice Rondinelli, Ewa Gogola, Hatice Yücel, Alexandra A. Duarte, Marieke van de Ven, Roxanne van der Sluijs, Panagiotis A. Konstantinopoulos, Jos Jonkers, Raphaël Ceccaldi, Sven Rottenberg, Alan D. D’Andrea

(2017 nov 01)

2017

Biallelic inactivation of REV7 is associated with Fanconi anemia

Journal of Clinical Investigation

Dominique Bluteau, Julien Masliah-Planchon, Connor Clairmont, Alix Rousseau, Raphael Ceccaldi, Catherine Dubois d’Enghien, Olivier Bluteau, Wendy Cuccuini, Stéphanie Gachet, Régis Peffault de Latour, Thierry Leblanc, Gérard Socié, André Baruchel, Dominique Stoppa-Lyonnet, Alan D. D’Andrea, Jean Soulier

(2017 Mar 01)

2016

Biallelic inactivation of REV7 is associated with Fanconi anemia

Journal of Clinical Investigation

(2016 Aoû 08)

2016

FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair

Cell Reports

Zeina Kais, Beatrice Rondinelli, Amie Holmes, Colin O’Leary, David Kozono, Alan D. D’Andrea, Raphael Ceccaldi

(2016 juin 01)

2016

Repair Pathway Choices and Consequences at the Double-Strand Break