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- Activated I-BAR IRSp53 clustering controls the formation of VASP-actin–based membrane protrusions
Activated I-BAR IRSp53 clustering controls the formation of VASP-actin–based membrane protrusions
Auteurs
Feng-Ching Tsai, J. Michael Henderson, Zack Jarin, Elena Kremneva, Yosuke Senju, Julien Pernier, Oleg Mikhajlov, John Manzi, Konstantin Kogan, Christophe Le Clainche, Gregory A. Voth, Pekka Lappalainen, Patricia Bassereau
Résumé
Filopodia are actin-rich membrane protrusions essential for cell morphogenesis, motility, and cancer invasion. How cells control filopodium initiation on the plasma membrane remains elusive. We performed experiments in cellulo, in vitro, and in silico to unravel the mechanism of filopodium initiation driven by the membrane curvature sensor IRSp53 (insulin receptor substrate protein of 53 kDa). We showed that full-length IRSp53 self-assembles into clusters on membranes depending on PIP
Equipes

Membres

PATRICIA BASSEREAU
Directeur de recherche CNRS