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- A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity
A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity
Auteurs
Alejandro Conde-Perez, Gwendoline Gros, Christine Longvert, Malin Pedersen, Valérie Petit, Zackie Aktary, Amaya Viros, Franck Gesbert, Véronique Delmas, Florian Rambow, Boris C. Bastian, Andrew D. Campbell, Sophie Colombo, Isabel Puig, Alfonso Bellacosa, Owen Sansom, Richard Marais, Leon C. L. T. Van Kempen, Lionel Larue
Résumé
Abstract
Loss of the tumour suppressor PTEN is frequent in human melanoma, results in MAPK activation, suppresses senescence and mediates metastatic behaviour. How PTEN loss mediates these effects is unknown. Here we show that loss of PTEN in epithelial and melanocytic cell lines induces the nuclear localization and transcriptional activation of β-catenin independent of the PI3K–AKT–GSK3β axis. The absence of PTEN leads to caveolin-1 (CAV1)-dependent β-catenin transcriptional modulation
Membres

VALERIE PETIT
Ingénieur de recherche
LIONEL LARUE
Directeur de recherche Inserm